The format of training family doctors on palliative care in the Dnipropetrovsk region.

The first global palliative care resolution WHA 67.19 has been developed recently, in 2014, where the need to improve access to palliative care around the world is first declared. In the article, the authors analyzed the change trends and the state of the medical care delivery system for incurable patients in the world and Ukraine. As the civilization of the state and the humanity of society as a whole is assessed by the level of PHC provision in today's world, this problem has attracted the attention of central (Ukraine) and regional (Dnipro city) government bodies, which was reflected in the search for new medical and educational initiatives. The need of the time is the need to focus the attention of family doctors on the issue that palliative care is a qualification component of their daily work, which will help to remove incurable patients from the periphery of attention of their multicomponent work, and will also help to clearly build the interaction between the primary and secondary link, in particular, with hospice departments of specialized hospitals. In particular, the experience of implementing a joint project of a new format for training family doctors on palliative care issues, realized by the Department of Family Medicine of the SE “DMA” and the Municipal non-commercial enterprise "City Clinical Hospital No. 2” of Dnipro City Council is described. In­novative forms of conducting classes help to expand the boundaries of the possibilities of teaching problematic issues of palliative medicine, which account for only 0.6% of instructional time in the existing program of training family doctors of secondary specialization, and the multicomponent format for studying palliative care issues, implemented, inter alia, with support of Director of the Municipal non-commercial enterprise "City Clinical Hospital No. 2” of Dnipro City Council (visiting hospice and palliative departments delivering secondary level of medical care assistance, a structured regulatory unit for the provision of PHC in Ukraine, working out of patients’ routing issues, interactive teaching methods, etc.) leaves in the memory of physician-trainees not only the essential content, but also a deep emotional trace, which helps to increase the motivation of the physician trainees, improves coordination between primary and secondary palliative care and improves the quality of training

Accessibility and usability of e-government web-resources: problems and solutions

The convenience and accessibility of e-government services largely determines the success in building/making/creating trusting online relationships with the population and reduces the inequality between different categories of citizens in terms of using online communications with public authorities. The purpose of the research is to identify the main flaws and problems in ensuring convenient and accessible use of public service portals by citizens on the basis of scientific and practical literature and to find approaches to their elimination. The article examines the foreign experience of creating comfortable conditions for electronic interaction of citizens with the government and lists the main errors in the development of interfaces and functionality of government websites and portals. In accordance with the international standards WCAG 2.1, the authors define the key criteria for the convenience and accessibility of web resources. Then they evaluate the compliance of the Gosuslugi web-portal with the formulated requirements and give recommendations on possible ways to improve Russian e-government web resources

Evolution of in vitro digestibility techniques: a systematic review

The inability to reproduce certain digestive processes in vivo, high research costs and ethical aspects have led to the development of a large number of in vitro digestion models. These models allow us to take into account various factors of modeling complex multistage physiological processes occurring in the gastrointestinal tract, which makes them promising and widely used. A significant part of in vitro methods includes assessment by enzymatic digestion and are based on the calculation of nitrogen remaining after digestion in relation to the initial total nitrogen (according to the Dumas, Kjeldahl method, spectrophotometric or chromatographic method). There are also a number of titrometric methods (pH‑stat), which are mainly used to assess the digestibility of feed, most successfully for aquatic animals due to the simplicity of their digestive tract. Methods for assessing the digestibility of food products by enzymatic digestion have undergone various stages of evolution (since 1947) and have been widely modified by including various enzymes (pepsin, trypsin, pancreatin, erepsin, etc.) in model systems, indices for various products have been determined on their basis (pepsin-digest-residue (PDR) index, 1956; pepsin pancreatin digest (PPD) index, 1964; pepsin digest dialysate (PDD), 1989). As a result, a single protocol was formed to study the digestibility of food — INFOGEST (2014–2019), which includes three stages of digestion (oral, gastric and intestinal). It allows researchers to accurately reproduce the conditions of the human gastrointestinal tract and is widely used by scientists around the world

Assessment of the role of the state in the management of mineral resources

Mineral resources as natural capital can be transformed into human, social and physical capital, that guarantees the sustainable development of a country, exclusively through professional public management. Public management of a country's mineral resource potential is seen as an element of transnational governance. Regulation involves the use of laws, rules and regulations within the jurisdictional and sectoral capabilities of the state, minimizing its involvement as a producer. The features of the ideology of economic liberalism, which polarizes the societies of raw material producing countries by imposing austerity, as well as lowering trade barriers have been studied. The analysis of the influence of the radical new order of neoliberal world ideology on the development of the extractive sector and the strengthening of state regulation has been presented

Оценка функционального состояния кожной микрогемодинамики методами допплеровской флоуметрии и спекл-метрии

The characteristics of blood microcirculation in human tissues have been investigated by recording and analyzing a dynamic speckle pattern. Methodical approaches have been proposed for evaluating the obtained data in order to verify speckle measurements using the widely used Doppler flowmetry technique.Исследованы характеристики микроциркуляции крови в тканях человека посредством регистрации и анализа динамической спекл-картины. Предложены методические подходы для оценки полученных данных с целью верификации спекл-измерений с помощью широко используемой методики допплеровской флоуметрии

МЕТАБОЛИЧЕСКИЕ И КЛИНИКО-РАДИОЛОГИЧЕСКИЕ ИЗМЕНЕНИЯ У ПАЦИЕНТОВ С СИМПТОМАТИЧЕСКОЙ ЭПИЛЕПСИЕЙ ПРИ РАЗОРВАВШИХСЯ АНЕВРИЗМАХ СОСУДОВ ГОЛОВНОГО МОЗГА

The results of the study of metabolic and clinical-radiological changes in patients of two groups with and without symptomatic epilepsy on the background of hemorrhages from ruptured arterial aneurysms are shown. The findings suggest that there is the development of hypoxic nature of violations with the activation of prooxidant reactions in both groups, however, in patients with symptomatic epilepsy was found a significant decrease in antioxidant activity of enzymatic and non-enzymatic cell protection systems with increasing the production of the proinflammatory cytokine TNF-alpha in contrast to the group of patients without epilepsy.Приведены результаты исследования метаболических и клинико-радиологических изменений у пациентов двух групп с симптоматической эпилепсией или без эпиприступов при кровоизлияниях из разорвавшихся артериальных аневризм. Полученные данные свидетельствуют о развитии нарушений гипоксического характера с активацией прооксидантных реакций в обеих группах, однако у пациентов с симптоматической эпилепсией установлено значительное снижение антиоксидантной активности ферментативных и неферментативных систем защиты клеток при повышении продукции провоспалительного цитокина ФНО-альфа в отличие от группы пациентов без эписиндрома

Влияние продолжительности светодиодного освещения на биохимический состав микрозелени капусты белокочанной

In recent years, there has been a steady increase in public interest in healthy and balanced foods all over the world. In this respect, the microgreens of white cabbage is a source of a wide range of useful substances and is characterized by a higher content of those, compared with a similar commercial vegetable. At the same time, information about technological aspects of cultivation, which relate to the duration of lighting, about their correlation with biochemical composition of microgreens of industrial varieties and hybrids of this crop is insufficient and is limited to a very narrow set of their parameters. For this reason, it is of particular relevance to identify the optimal duration of LED lighting in the white cabbage microgreens crop, which ensures accumulation of the highest nutritional and vitamin value and determines the taste qualities of this product. The results of a comparative study of 14 quantitative parameters of biochemical composition of white cabbage microgreens (content of dry, tannic and pectin substances, free organic, ascorbic and hydroxycinnamic acids, soluble sugars, the main groups of bioflavonoids – i.e. anthocyanins, leucoanthocyanins, catechins, flavonols and the indicator of sugar acid index) with different duration of LED lighting are presented (8, 10, 12, 14 and 16 hours). The less significant effect of the studied factor on biochemical composition of microgreens was revealed at 10 hour exposure, while the maximum, exceeding it three times, was at 16 hour exposure. It has been shown that the highest integral level of nutritional and vitamin value of products according to the total analyzed indicators was provided at 16 hours of LED lighting, while the minimum – at 8 hours. For the first time in the Republic of Belarus, the optimal duration of LED lighting for the accumulation of physiologically valuable compounds by microgreens of white cabbage was revealed, which made it possible to recommend it to be used for industrial production.В последние годы во всем мире наблюдается устойчивое повышение интереса общества к здоровым и сбалансированным продуктам питания. Микрозелень капусты белокочанной в этом отношении является источником широкого спектра полезных веществ и отличается более высоким их содержанием по сравнению с аналогичным товарным овощем. Вместе с тем информация о технологических аспектах выращивания, к которым в первую очередь относится продолжительность освещения, об их связи с биохимическим составом микрозелени промышленных сортов и гибридов данной культуры недостаточна и ограничивается весьма узким набором их характеристик. По этой причине особую актуальность обретает выявление оптимальной продолжительности светодиодного освещения в культуре микрозелени капусты белокочанной, обеспечивающей накопление наиболее высокой питательной и витаминной ценности и определяющей вкусовые качества данной продукции. Приведены результаты сравнительного исследования 14 количественных характеристик биохимического состава микрозелени капусты белокочанной (содержание сухих, дубильных и пектиновых веществ, свободных органических, аскорбиновой и гидроксикоричных кислот, растворимых сахаров, основных групп биофлавоноидов – собственно антоцианов, лейкоантоцианов, катехинов, флавонолов и показатель сахарокислотного индекса) при разной продолжительности светодиодного освещения (8, 10, 12, 14, 16 ч). Наименее значительное влияние исследуемого фактора на биохимический состав микрозелени выявлено при 10-часовой экспозиции, тогда как максимальное, превышавшее его в три раза, – при 16-часовой. Показано, что наиболее высокий интегральный уровень питательной и витаминной ценности продукции по совокупности анализируемых показателей обеспечивался при 16-часовой продолжительности светодиодного освещения, тогда как минимальный – при 8-часовой. Впервые в Республике Беларусь выявлена оптимальная продолжительность светодиодного освещения для накопления физиологически ценных соединений микрозеленью капусты белокочанной, что дало возможность рекомендовать ее для использования при промышленном производстве данной продукции

ВЛИЯНИЕ ПОГОДНЫХ УСЛОВИЙ НА ИЗМЕНЧИВОСТЬ ХАРАКТЕРИСТИК БИОХИМИЧЕСКОГО СОСТАВА ПЛОДОВ ИНТРОДУЦИРОВАННЫХ СОРТОВ OXYCOCCUS MACROCARPUS (AIT.) PERS. В УСЛОВИЯХ БЕЛАРУСИ

The article presents the results of a comparative study of the variability of the biochemical composition of the fruits of six cultivars introduced in Belarus: Oxycoccus macrocarpus (Ait.) Pers. – Stevens, Bain Favorit, Hiliston, Holistar Red, Stankovic and WSU 108 during contrast moistening seasons. It has been established that the least pronounced intersectional differences are characterized by the parameters of accumulation in the fruits of dry substances, ascorbic and hydroxycinnamic acids, as well as the total amount of antoniated pigments and bioflavonoids in general, while of most significance are the sugar-dependent concentration and the content of soluble sugars, pectins, leucoanthocyanins and flavonols. It is shown that in the taxonomic series of large-fruited cranberries the Stankovich cultivar was characterized by the greatest resistance of the biochemical composition of the fruits to weather factors, while the lowest cultivar was Bain Favorit and especially Hiliston. Приведены результаты сравнительного исследования изменчивости биохимического состава плодов 6 новых интродуцированных в Беларуси сортов: Oxycoccus macrocarpus (Аit.) Рers. – Stevens, Bain Favorit, Hiliston, Holistar Red, Stankovich и WSU 108 в контрастные по режиму увлажнения сезоны. Установлено, что наименее выраженными межсезонными различиями характеризовались параметры накопления в плодах сухих веществ, аскорбиновой и гидроксикоричных кислот, а также общее количество антоциановых пигментов и биофлавоноидов в целом, тогда как наиболее значительными – показатель сахарокислотного индекса и содержание в них растворимых сахаров, пектиновых веществ, лейкоантоцианов и флавонолов. Показано, что в таксономическом ряду клюквы крупноплодной наибольшей устойчивостью биохимического состава плодов к погодным факторам характеризовался сорт Stankovich, тогда как наименьшей – сорта Bain Favorit и особенно Hiliston.